Stanford Medcast Episode 40: Hot Topics Mini-Series - The Role of Epstein-Barr Virus in Multiple Sclerosis

This Hot Topics Mini-Series episode includes a discussion with Dr. Lawrence Steinman, professor of Neurology and Neurological Sciences, Pediatrics, and Genetics at Stanford Medical School. Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system. In people with MS, the body’s immune system attacks the insulating layer that surrounds nerve cells, often killing the cells. In this episode, Dr. Steinman unpacks the connection between the Epstein-Barr virus and MS and the implications for the development of new vaccines and anti-virals that have the potential to eradicate this disease.

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1. Analyze the link between the Epstein-Barr Virus and development of Multiple Sclerosis.

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Credit Designation 
American Medical Association (AMA) 
Stanford Medicine designates this Enduring Material for a maximum of 0.50 AMA PRA Category 1 Credits^TM.  Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

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Cultural and Linguistic Competency
The planners and speakers of this CME activity have been encouraged to address cultural issues relevant to their topic area for the purpose of complying with California Assembly Bill 1195. Moreover, the Stanford University School of Medicine Multicultural Health Portal contains many useful cultural and linguistic competency tools including culture guides, language access information and pertinent state and federal laws.  You are encouraged to visit the Multicultural Health Portal: https://laneguides.stanford.edu/multicultural-health

References/Bibliography
1.Lanz, TV, Brewer, RC, Ho, PP et al. (2022). Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM. Nature. 603, 321–327. https://doi.org/10.1038/s41586-022-04432-7
2.Doctrow, B. (2022, Feb 1). Study suggests Epstein-Barr virus may cause multiple sclerosis. National Institutes of Health. https://www.nih.gov/news-events/nih-research-matters/study-suggests-epstein-barr-virus-may-cause-multiple-sclerosis
3.Pender, M. P., & Burrows, S. R. (2014). Epstein-Barr virus and multiple sclerosis: potential opportunities for immunotherapy. Clinical & translational immunology, 3(10), e27. https://doi.org/10.1038/cti.2014.25

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Mitigation of Relevant Financial Relationships

Stanford Medicine adheres to the Standards for Integrity and Independence in Accredited Continuing Education.

There are no relevant financial relationships with ACCME-defined ineligible companies for anyone who was in control of the content of this activity, except those listed in the table below. All of the relevant financial relationships listed for these individuals have been mitigated.

Member Information

Role in activity

Nature of Relationship(s) / Name of Ineligible Company(s)

Ruth Adewuya, MD
Managing Director
Stanford University

Course Director and Reviewer

Nothing to disclose

Lawrence Steinman, MD
Stanford University

Faculty

Consulting Fee-Bristol-Myers Squibb|Consulting Fee-Atara |Consulting Fee-TG Therapeutics|Grant or research support-Roche|Membership on Advisory Committees or Review Panels, Board Membership, etc.-Pasithea|Membership on Advisory Committees or Review Panels, Board Membership, etc.-BioAtla|Membership on Advisory Committees or Review Panels, Board Membership, etc.-180 Life Sciences

Ishita Verma
Student
Stanford University

Planner

Nothing to disclose

This CME Activity is supported in by an educational grant from Novartis Pharmaceuticals Corporation.