Stanford Medcast Episode 107: Hot Topics Mini-Series: Gut Check - How the Microbiome Shapes CAR-T Therapy Outcomes

The microbiome is emerging as a key player in the effectiveness of CAR-T therapy, and today, Dr. Melody Smith, Assistant Professor of Medicine at Stanford University, sheds light on this fascinating intersection. Join us as we explore how advancements in CAR T-cell therapy are reshaping patient demographics and treatment approaches. Dr. Smith will discuss the implications of genetic engineering techniques like CRISPR, the importance of a multidisciplinary treatment strategy, and the role of antibiotic stewardship in optimizing outcomes. With insights into innovative therapies and ongoing clinical trials, this conversation promises to deepen your understanding of CAR-T therapy and its complexities, offering a glimpse into the future of cancer treatment.

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1. Discuss how CAR T cell therapy has transformed outcomes for patients.
2. Understand the connections between the gut microbiome and effective CAR T cell therapy.

In support of improving patient care, Stanford Medicine is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. 
 
Credit Designation 
American Medical Association (AMA) 
Stanford Medicine designates this Enduring Material for a maximum of 0.50 AMA PRA Category 1 Credits^TM.  Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

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Cultural and Linguistic Competency
The planners and speakers of this CME activity have been encouraged to address cultural issues relevant to their topic area for the purpose of complying with California Assembly Bill 1195. Moreover, the Stanford University School of Medicine Multicultural Health Portal contains many useful cultural and linguistic competency tools including culture guides, language access information and pertinent state and federal laws.  You are encouraged to visit the Multicultural Health Portal: https://laneguides.stanford.edu/multicultural-health

References/Bibliography
1. Lockwood, M. B., & Green, S. J. (2020, June 19). Clinical care is evolving: The microbiome for advanced practice nurses. Journal of the American Association of Nurse Practitioners. https://pmc.ncbi.nlm.nih.gov/articles/PMC7304310/

2. Dodou, K., & Whiteley, P. (2013, March 2). Microbiomics: Its Growing Significance in the World of Medicines Testing. The Pharmaceutical Journal.

3. Smith, M, et. al. (2022, April 28). Gut microbiome correlates of response and toxicity following anti-cd19 car T cell therapy. Nature Medicine. https://pubmed.ncbi.nlm.nih.gov/35288695/

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     Email: [email protected]

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Mitigation of Relevant Financial Relationships

Stanford Medicine adheres to the Standards for Integrity and Independence in Accredited Continuing Education.

There are no relevant financial relationships with ACCME-defined ineligible companies for anyone who was in control of the content of this activity, except those listed in the table below. All of the relevant financial relationships listed for these individuals have been mitigated.

Member Information

Role in activity

Nature of Relationship(s) / Name of Ineligible Company(s)

Ruth Adewuya, MD
Managing Director
Stanford University

Course Director, Reviewer

Nothing to disclose

Melody Smith, MD
Assistant Professor of Medicine (Blood and Marrow Transplantation)
Stanford University School of Medicine

Faculty

Advisor-A28 Therapeutics|Consulting Fee-CVS Caremark

Lydia Wang
Medcast Intern
Stanford

Planner

Nothing to disclose