Using new tools to find seizing neurons in mice / Neural circuitry of the gut in models of neural tube defects | Neurology Grand Rounds (RECORDING)

Tuesday, December 3, 2024, 12:00 AM - Thursday, December 2, 2027, 11:59 PM, On Demand

In this recorded combined Neurology Grand Rounds resident research presentation, Stanford Neurology Resident Dr. David Hartman begins by presenting his research on using new tools to find seizing neurons in mice, focusing on temporal lobe epilepsy. He discusses the use of SC-Flare, a technique developed by the Ting Lab, to identify cells participating in seizures. Dr. Hartman highlights the discovery of the fasciola cinereum (FC) as an important seizure focus, which was later confirmed in human patients. He emphasizes the mosaic nature of seizure foci, where some neurons participate in seizures while others do not. 
The presentation then moves on to Stanford Neurology Resident, Dr. Gabby Barsh, who discusses developmental neurobiology, specifically focusing on neural tube defects and their impact on the enteric nervous system. Dr. Barsh outlines research using mouse models to study both extrinsic and intrinsic neural circuitry of the gut during development. She presents preliminary data on the role of Frizzled 3, a planar cell polarity protein, in organizing enteric neurons. Dr. Barsh concludes by outlining future research plans, including studying enteric neuron structure and function in genetic and teratogenic models of neural tube defects.


  Release Date: December 03, 2024
  Expiration Date: December 02, 2027
  Estimated Time to Complete: 0.5 hours
  Registration Fee: FREE
 *Originally recorded 05/03/2024

AMA PRA Category 1 Credits™ (0.50 hours), Non-Physician Participation Credit (0.50 hours)

1. Discuss the use of SC-Flare
2. Highlight the discovery of the fasciola cinereum (FC) as an important seizure focus
3. Highlight the discovery of the fasciola cinereum (FC) as an important seizure focus
4. Examine enteric neuron structure and function in genetic models of neural tube defects using the Frizzle 3 mutant
5. Conceptualize the extrinsic innervation of the GI tract in neural tube defect models in future research

In support of improving patient care, Stanford Medicine is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. 

Credit Designation 
American Medical Association (AMA) 
Stanford Medicine designates this Enduring Material for a maximum of 0.50 AMA PRA Category 1 Credits^TM.  Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

Accessibility Statement
 Stanford University School of Medicine is committed to ensuring that its programs, services, goods and facilities are accessible to individuals with disabilities as specified under Section 504 of the Rehabilitation Act of 1973 and the Americans with Disabilities Amendments Act of 2008.  If you have needs that require accommodations, please contact the CME Office.

Cultural and Linguistic Competency
The planners and speakers of this CME activity have been encouraged to address cultural issues relevant to their topic area for the purpose of complying with California Assembly Bill 1195. Moreover, the Stanford University School of Medicine Multicultural Health Portal contains many useful cultural and linguistic competency tools including culture guides, language access information and pertinent state and federal laws.  You are encouraged to visit the Multicultural Health Portal: https://laneguides.stanford.edu/multicultural-health

For References/Bibliography click here

For CME general questions, please contact 
     Email: [email protected]

Mitigation of Relevant Financial Relationships

Stanford Medicine adheres to the Standards for Integrity and Independence in Accredited Continuing Education.

There are no relevant financial relationships with ACCME-defined ineligible companies for anyone who was in control of the content of this activity. 

Faculty Member Information	Role in activity	Name of commercial interest/Nature of relationship
Kate Therkelsen, MD	Course Director	Nothing to Disclose
Tara Torabi, MD	Planner	Nothing to Disclose
Rachel Walsh, MD	Planner	Nothing to Disclose
Gregory Wong, MD	Planner and Reviewer	Nothing to Disclose
Jose Eduardo Espindola Lima, MD	Planner and Reviewer	Nothing to Disclose
David Hartman, MD, PhD	Faculty	Nothing to Disclose
Gabby Barsh, MD, PhD	Faculty	Nothing to Disclose