Pediatric Grand Rounds (RECORDING) Does the Shoe Fit? Adult Guideline Directed Medical Therapy and the Failing Pediatric Heart

This presentation is a recording of a Stanford Pediatric Grand Rounds Session.  World-renowned experts will present the latest research, practice guidelines, and treatment protocols to advance best practices in the care of pediatric patients. These online recordings will provide pediatricians and family physicians with up-to-date clinical information on a wide range of clinical issues encountered in daily pediatric practice. There is a growing body of evidence suggesting that the pediatric failing heart has differential adaptation to heart failure based on age and the underlying etiology of heart failure. Therefore, while application of GDMT in children continues to be reasonable, there needs to be acknowledgement of the lack of evidence specific to pediatric heart failure. In order for outcomes to improve a new paradigm is likely needed. Expansion of explanted heart tissue and biomarker work, development of animal and cell-based model systems for mechanistic studies, and innovative clinical trial design approaches are necessary to identify novel and efficacious age and etiology specific therapies.

  Release Date: March 23, 2023
  Expiration Date: March 22, 2024
  Estimated Time to Complete: 1.0 hour
  Registration Fee: FREE
 *Originally recorded 02/17/2023.

1. Review the differences in outcome between children and adults with heart failure.
2. Describe some of the differences seen in the failing myocardium of children compared to adults.
3. Discuss a novel model using serum from children with heart failure to study cardiomyocyte remodeling

In support of improving patient care, Stanford Medicine is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. 

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American Medical Association (AMA) 
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Mitigation of Relevant Financial Relationships

Stanford Medicine adheres to the Standards for Integrity and Independence in Accredited Continuing Education. 

There are no relevant financial relationships with ACCME-defined ineligible companies for anyone who was in control of the content of this activity, except those listed in the table below. All of the relevant financial relationships listed for these individuals have been mitigated.

Member Information

Role in activity

Nature of Relationship(s) / Name of Ineligible Company(s)

Alan R. Schroeder, MD
Clinical Professor
Stanford University

Co-Course Director

Nothing to disclose

Olivera Marsenic Couloures, MD
LPCH

Course Director and Reviewer

Nothing to disclose

Shelley Miyamoto, MD
University of Colorado Anschutz Medical Campus

Faculty

Nothing to disclose

Debra Babcock, MD
Stanford Childrens (PCHA)

Planner

Nothing to disclose

Lisa Jo Chamberlain, MD
Professor of Pediatrics – General Pediatrics
Stanford Children's Health

Planner

Nothing to disclose

Baraka Dechelle Floyd, MD
Clinical Assistant Professor and Associate Chair for Diversity, Equity, and Inclusion
Stanford University School of Medicine

Planner

Nothing to disclose

Charles Gawad, MD, PhD
Associate Professor
Stanford

Planner

Ownership-BioSkryb Genomics

Allison Guerin, EdD
Stanford

Planner

Nothing to disclose

Mary Beth Leonard, MD, MSCE
Arline and Pete Harman Professor and Chair, Department of Pediatrics
Stanford University

Planner

Nothing to disclose

Ryan Lion, MD, MS
Stanford University

Planner

Nothing to disclose

Lauren E O'Brien, MD
Clinical Assistant Professor
LPCH

Planner

Nothing to disclose

Stephen J Roth, MPH, MD
Attending, Cardiovascular ICU
Lucile Packard Children's Hospital Stanford

Planner

Nothing to disclose

Stephanie Squires, MD
Pediatric Hospital Medicine Fellow
Stanford Health Care/ Stanford Children's Hospital

Planner

Nothing to disclose

Ke-You Zhang, MD
Stanford University

Planner

Nothing to disclose