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Pediatric Grand Rounds (RECORDING) Predicting Patient Outcomes from Single Cells in Childhood Cancer


Pediatric Grand Rounds (RECORDING) Predicting Patient Outcomes from Single Cells in Childhood Cancer Banner

  • Overview
  • Faculty
  • Begin


Date & Location
Wednesday, June 15, 2022, 12:00 AM - Wednesday, June 14, 2023, 11:59 PM

Overview

This presentation is a recording of a Stanford Pediatric Grand Rounds Session.  World-renowned experts will present the latest research, practice guidelines, and treatment protocols to advance best practices in the care of pediatric patients. These online recordings will provide pediatricians and family physicians with up-to-date clinical information on a wide range of clinical issues encountered in daily pediatric practice. 

Acute lymphoblastic leukemia (ALL) is the most common cancer of childhood and one of the deadliest despite impressive improvements in survival. The Davis lab uses single-cell, high-dimensional analysis to identify the most important cells, those that are resistant to standard and cutting-edge therapies, leading to relapse. By identifying and understanding these treatment resistant cells can we work to prevent relapse and cure more children and young adults with ALL.


Registration

  Release Date: June 15, 2022
  Expiration Date: June 14, 2023
  Estimated Time to Complete: 1.0 hour
  Registration Fee: FREE
 *Originally recorded 03/25/2022.


Credits
AMA PRA Category 1 Credits™ (1.00 hours), Non-Physician Participation Credit (1.00 hours)

Target Audience
Specialties - Oncology, Pediatrics
Professions - Fellow/Resident, Non-Physician, Physician, Student

Objectives
At the conclusion of this activity, participants should be able to:

  1. Recognize current clinical outcomes and challenges in childhood acute lymphoblastic leukemia.
  2. Recognize developmental structure of B cell ALL.
  3. Describe impact of single-cell approaches to identify clinically relevant cell populations in ALL.

Accreditation

In support of improving patient care, Stanford Medicine is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. 

Credit Designation 
American Medical Association (AMA) 
Stanford Medicine designates this Enduring Material for a maximum of 1.00 AMA PRA Category 1 CreditsTM.  Physicians should claim only the credit commensurate with the extent of their participation in the activity.


Additional Information

Accessibility Statement
 Stanford University School of Medicine is committed to ensuring that its programs, services, goods and facilities are accessible to individuals with disabilities as specified under Section 504 of the Rehabilitation Act of 1973 and the Americans with Disabilities Amendments Act of 2008.  If you have needs that require accommodations, please contact the CME Conference Coordinator.

Cultural and Linguistic Competency
The planners and speakers of this CME activity have been encouraged to address cultural issues relevant to their topic area for the purpose of complying with California Assembly Bill 1195. Moreover, the Stanford University School of Medicine Multicultural Health Portal contains many useful cultural and linguistic competency tools including culture guides, language access information and pertinent state and federal laws.  You are encouraged to visit the Multicultural Health Portal: https://laneguides.stanford.edu/multicultural-health

References/Bibliography

Asnani, M., Hayer, K. E., Naqvi, A., et al. (2020). Retention of CD19 intron 2 contributes to CART-19 resistance in leukemias with subclonal frameshift mutations in CD19. Leukemia 34, 1202–1207. https://doi.org/10.1038/s41375-019-0580-z

Bagashev, A., Sotillo, E., Tang, C. H., Black, K. L., Perazzelli, J., Seeholzer, S. H., Argon, Y.,

Barrett, D. M., Grupp, S. A., Hu, C. C., & Thomas-Tikhonenko, A. (2018). CD19 Alterations Emerging after CD19-Directed Immunotherapy Cause Retention of the Misfolded Protein in the Endoplasmic Reticulum. Molecular and cellular biology, 38(21), e00383-18. https://doi.org/10.1128/MCB.00383-18

Bendall, S. C., Davis, K. L., Amir, E., et al. (2014). Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development. Cell, 157(3), 714–725. https://doi.org/10.1016/j.cell.2014.04.005

Cain, D. W., & Cidlowski, J. A. (2017). Immune regulation by glucocorticoids. Nature reviews. Immunology, 17(4), 233–247. https://doi.org/10.1038/nri.2017.1

Chan, L., Chen, Z., Braas, D. et al. (2017). Metabolic gatekeeper function of B-lymphoid transcription factors. Nature 542, 479–483. https://doi.org/10.1038/nature21076

Churchman, M. L., Qian, M., Te Kronnie, G., Zhang, R., Yang, W., Zhang, H., Lana, T., Tedrick, P., Baskin, R., Verbist, K., Peters, J. L., Devidas, M., Larsen, E., Moore, I. M., Gu, Z., Qu, C., Yoshihara, H., Porter, S. N., Pruett-Miller, S. M., Wu, G., … Mullighan, C. G. (2018). Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia. Cancer Cell, 33(5), 937–948.e8. https://doi.org/10.1016/j.ccell.2018.03.021

Geng, H., et al. (2015). Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia. Cancer cell, 27(3), 409–425. https://doi.org/10.1016/j.ccell.2015.02.003

Gittins, R. (1933). Studies in the Anaemias of Infancy and Early Childhood: Part VIII Leukaemia (leucosis) in Children. Archives of Diseases of Childhood. https://adc.bmj.com/content/archdischild/8/47/291.full.pdf

Good, Z., Sarno, J., Jager, A., Samusik, N., Aghaeepour, N., Simonds, E. F., White, L., Lacayo, N. J., Fantl, W. J., Fazio, G., Gaipa, G., Biondi, A., Tibshirani, R., Bendall, S. C., Nolan, G. P., & Davis, K. L. (2018). Single-cell developmental classification of B cell precursor acute lymphoblastic leukemia at diagnosis reveals predictors of relapse. Nature medicine, 24(4), 474 483. https://doi.org/10.1038/nm.4505

Greaves, M. F. (1986). Differentiation-linked leukemogenesis in lymphocytes. Science (New York, N.Y.), 234(4777), 697–704. https://doi.org/10.1126/science.3535067

Hunger, S. P. & Mullighan, C. G. (2015). Acute Lymphoblastic Leukemia in Children. The New England Journal of Medicine 2015;373:1541-1552. https://doi.org/10.1056/NEJMra1400972

Inaba, H., & Mullighan, C. G. (2021). Pediatric acute lymphoblastic leukemia. Haematologica 2020;105(11):2524-2539. https://doi.org/10.3324/haematol.2020.247031

Jacoby, E., Nguyen, S., Fountaine, T., et al. (2016). CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity. Nature Communications, vol. 7, 12320. https://doi.org/10.1038/ncomms12320

Liu, Y., Davis, K., et al. (2021). Inhibition of Pre-BCR Signaling Mediates a Metabolic Switch in B-Cell Progenitor Acute Lymphoblastic Leukemia. American Society of Hematology, vol. 138 (1:615). https://doi.org/10.1182/blood-2021-145956

Maude, S. et al. (2018). Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia. The New England Journal of Medicine 2018;378:439-48. https://doi.org/10.1056/NEJMoa1709866

Mullighan, C. G., Miller, C. B., Radtke, I., Phillips, L. A., Dalton, J., Ma, J., White, D., Hughes, T. P., Le Beau, M. M., Pui, C. H., Relling, M. V., Shurtleff, S. A., & Downing, J. R. (2008). BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature, 453(7191), 110–114. https://doi.org/10.1038/nature06866

Mullighan, C. G., Su, X., Zhang, J., Radtke, I., Phillips, L. A., Miller, C. B., Ma, J., Liu, W., Cheng, C., Schulman, B. A., Harvey, R. C., Chen, I. M., Clifford, R. J., Carroll, W. L., Reaman, G., Bowman, W. P., Devidas, M., Gerhard, D. S., Yang, W., Relling, M. V., … Children's Oncology Group (2009). Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. The New England Journal of Medicine, 360(5), 470–480. https://doi.org/10.1056/NEJMoa0808253

Nguyen, K., Devidas, M., Cheng, S. C., La, M., Raetz, E. A., Carroll, W. L., Winick, N. J., Hunger, S. P., Gaynon, P. S., Loh, M. L., & Children's Oncology Group. (2008). Factors influencing survival after relapse from acute lymphoblastic leukemia: a Children's Oncology Group study. Leukemia, 22(12), 2142–2150. https://doi.org/10.1038/leu.2008.251

Sotillo, E., Barrett, D. M., Black, K. L., Bagashev, A., Oldridge, D., Wu, G., Sussman, R., Lanauze, C., Ruella, M., Gazzara, M. R., Martinez, N. M., Harrington, C. T., Chung, E. Y., Perazzelli, J., Hofmann, T. J., Maude, S. L., Raman, P., Barrera, A., Gill, S., Lacey, S. F., … Thomas-Tikhonenko, A. (2015). Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy. Cancer discovery, 5(12), 1282–1295. https://doi.org/10.1158/2159-8290.CD-15-1020

Sun, W. et al. (2018). Outcome of children with multiply relapsed B-cell acute lymphoblastic leukemia: a therapeutic advances in childhood leukemia & lymphoma study. Leukemia,
32(11), 2316–2325. https://doi.org/10.1038/s41375-018-0094-0

Tsuchida, M., Ikuta, K., Hanada, R., Saito, T., Isoyama, K., Sugita, K., Toyoda, Y., Manabe, A., Koike, K., Kinoshita, A., Maeda, M., Ishimoto, K., Sato, T., Okimoto, Y., Kaneko, T., Kajiwara, M., Sotomatsu, M., Hayashi, Y., Yabe, H., Hosoya, R., Nakazawa, S. (2000). Long-term follow-up of childhood acute lymphoblastic leukemia in Tokyo Children's Cancer Study Group 1981-1995. Leukemia, 14(12), 2295–2306. https://doi.org/10.1038/sj.leu.2401937

Van Zelm, M. et al. (2010). CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI39748

For CME general questions, please contact 
 
   Email: [email protected]



Mitigation of Relevant Financial Relationships


Stanford Medicine adheres to the Standards for Integrity and Independence in Accredited Continuing Education. 

There are no relevant financial relationships with ACCME-defined ineligible companies for anyone who was in control of the content of this activity, except those listed in the table below. All of the relevant financial relationships listed for these individuals have been mitigated.



Member Information
Role in activity
Nature of Relationship(s) / Name of Ineligible Company(s)
Alan R. Schroeder, MD
Clinical Professor
Stanford University
Co-Course Director and Reviewer
Nothing to disclose
Kara Lynn Davis, DO
Assistant Professor
Stanford University
Faculty
Grant or research support-Jazz Pharmaceuticals (Relationship has ended)|Membership on Advisory Committees or Review Panels, Board Membership, etc.-Novartis AG (Relationship has ended)
Debra Babcock, MD
Stanford Childrens (PCHA)
Planner
Nothing to disclose
Caitlin Billingham, MD, MPH
Chief Resident
Stanford Pediatrics
Planner
Nothing to disclose
Faculty Photos
Lisa Jo Chamberlain, MD
Professor of Pediatrics – General Pediatrics
Stanford Children's Health
Planner
Nothing to disclose
Olivera Marsenic Couloures, MD
LPCH
Planner
Nothing to disclose
Lane Donnelly, MD
University of North Carolina
Planner
Nothing to disclose
Faculty Photos
Baraka Dechelle Floyd, MD
Clinical Assistant Professor and Associate Chair for Diversity, Equity, and Inclusion
Stanford University School of Medicine
Planner
Nothing to disclose
Ingrid Garnica, Other
Stanford Pediatrics
Planner
Nothing to disclose
Charles Gawad, MD, PhD
Associate Professor
Stanford
Planner
Ownership-BioSkryb Genomics
Faculty Photos
Allison Guerin, EdD
Stanford
Planner
Nothing to disclose
Faculty Photos
Mary Beth Leonard, MD, MSCE
Arline and Pete Harman Professor and Chair, Department of Pediatrics
Stanford University
Planner
Nothing to disclose
Stephen J Roth, MPH, MD
Attending, Cardiovascular ICU
Lucile Packard Children's Hospital Stanford
Planner
Nothing to disclose
Sarina Tom, BA
Education Operations Manager
Stanford Pediatrics
Planner
Nothing to disclose
Ke-You Zhang, MD
Stanford University
Planner
Nothing to disclose

Predicting Patient Outcomes from Single Cells in Childhood Cancer
INSTRUCTIONS:  Click the Launch Video button to watch the video on YouTube. Next, click the Attestation button. Attest to your participation, view results, and complete the evaluation. After successful completion, your credit transcript will be available to view and download immediately in MY CE portal. 

Can’t find the evaluation? Click the MY CE button and select the Evaluation and Certificates tile. Select the Complete Evaluation button associated with the activity. 
Launch Video

 

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