Evaluation of Regional Tau Asymmetry / Chronic Jet Lag and the Developing Brain | Neurology Grand Rounds (RECORDING)

Thursday, December 12, 2024, 12:00 AM - Saturday, December 11, 2027, 11:59 PM, On Demand

In this recorded Neurology Grand Rounds combined Resident research presentation, Dr. Nick Schwartz from Beth Mormino's lab presents on regional tau asymmetry in PET imaging for Alzheimer's disease. He discusses the importance of tau PET imaging, its advantages over amyloid PET, and his research on tau asymmetry. Dr. Schwartz analyzes data from ADNI and A4 studies, focusing on six brain regions. He found that laterality index increases with age but decreases with increased amyloid. Laterality seems to worsen MOCA scores in clinically unimpaired patients and potentially affects cognitive domains in dementia stages. His research suggests a model where individuals gain laterality over time, reach a maximum, then revert to a more symmetrical state, possibly mediated by increased amyloid. He then expresses plans to further investigate this in other cohorts and apply machine learning techniques.

In the second part of the combined Resident research lecture, Dr. Ann Robbins presents research on circadian rhythms in the oligodendrocyte lineage, conducted in Erin Gibson's lab. She provides an overview of the circadian system, its disruption effects, and focused on the oligodendrocyte lineage. Dr. Robbins discusses ongoing experiments using a chronic jet lag model in pregnant mice to study the effects of circadian disruption on oligodendrocyte precursor cells (OPCs) and myelination in offspring. Preliminary results showed increased OPC proliferation but similar cell density in the corpus callosum of mice subjected to chronic jet lag in utero. Dr. Robbins emphasizes the need for further replication and investigation of these findings, including additional models of circadian misalignment and further histology and electron microscopy studies.

  Release Date: December 12, 2024
  Expiration Date: December 11, 2027
  Estimated Time to Complete: 0.5 hours
  Registration Fee: FREE
 *Originally recorded 05/03/2024

AMA PRA Category 1 Credits™ (0.50 hours), Non-Physician Participation Credit (0.50 hours)

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American Medical Association (AMA) 
Stanford Medicine designates this Enduring Material for a maximum of 0.50 AMA PRA Category 1 Credits^TM.  Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

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Mitigation of Relevant Financial Relationships

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There are no relevant financial relationships with ACCME-defined ineligible companies for anyone who was in control of the content of this activity. 

Faculty Member Information	Role in activity	Name of commercial interest/Nature of relationship
Kate Therkelsen, MD	Course Director	Nothing to Disclose
Tara Torabi, MD	Planner	Nothing to Disclose
Rachel Walsh, MD	Planner	Nothing to Disclose
Gregory Wong, MD	Planner and Reviewer	Nothing to Disclose
Jose Eduardo Espindola Lima, MD	Planner and Reviewer	Nothing to Disclose
Nicholas Schwartz, MD, PhD	Faculty	Nothing to Disclose
Ann Robbins, MD, PhD	Faculty	Nothing to Disclose