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Stanford Pain Relief Innovations Lab Guest Speaker Series: Self-Fulfilling Prophecies: How Predictions and Expectations Modulate Pain (RECORDING)


Stanford Pain Relief Innovations Lab Guest Speaker Series: Self-Fulfilling Prophecies: How Predictions and Expectations Modulate Pain (RECORDING) Banner

  • Overview
  • Faculty
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Date & Location
Friday, July 7, 2023, 12:00 AM - Monday, July 6, 2026, 11:59 PM, On Demand

Overview
The Stanford Pain Relief Innovations Lab, hosted by Dr. Beth Darnall, PhD, presents an online guest speaker series, inviting visiting professors in Pain Medicine, Pain Management and Pain Science. This topic is "Self-Fulfilling Prophecies: How Predictions and Expectations Modulate Pain" presented by Howard Fields, MD, PhD. During this lecture, Dr. Fields discussed circuitry for pain sensation and modulation, predictive cues for pain, and how opioid analgesics work in the brain.

Registration

  Release Date: July 7, 2023
  Expiration Date: July 6, 2026
  Estimated Time to Complete: 1.0 hour
  Registration Fee: FREE
 *Originally recorded 09/09/2022

For Pharmacists to Claim ACPE Credit:

If you wish to apply for ACPE credit, please enter your NABP ePID# and Date of Birth in your CE Profile.
Log in to Stanford's CME portal > My CE > Profile tile > Credentials > Select NABP ePID# from the drop down and enter your ID number.
Please also enter your Date of Birth (month and day) in your profile under Basic Information.  The field will appear when you select your Profession as Pharmacist.

View more DEA MATE resources and training accredited by Stanford CME at https://med.stanford.edu/cme/dea.html


Credits
AMA PRA Category 1 Credits™ (1.00 hours), AAPA Category 1 CME credits (1.00 hours), ACPE Contact Hours (1.00 hours), ANCC Contact Hours (1.00 hours), APA Continuing Education credits (1.00 hours), ASWB Continuing Education (ACE) credits (1.00 hours), Non-Physician Participation Credit (1.00 hours)

Target Audience
Specialties - Pain Medicine
Professions - Advance Practice Nurse (APN), Fellow/Resident, Non-Physician, Nurse, Pharmacist, Pharmacy Technician , Physician, Physician Associate, Psychologist, Registered Nurse (RN), Social Worker, Student

Objectives
At the conclusion of this activity, learners should be able to:

  1. Recognize the basic circuitry for pain sensation and modulation.
  2. Identify how predictive cues can increase or decrease pain.
  3. Discuss how opioid analgesics work in the brain.

Accreditation

In support of improving patient care, Stanford Medicine is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. 

Credit Designation 
American Medical Association (AMA) 
Stanford Medicine designates this Enduring Material for a maximum of 1.00 AMA PRA Category 1 CreditsTM.  Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

Accreditation Council of Pharmacy Education (ACPE) 
Stanford Medicine designates this knowledge-based activity for a maximum of 1.0 hours. Credit will be provided to NABP CPE Monitor within 60 days after the activity completion. 

UAN#: JA0000751-0000-23-013-H08-P

American Nurses Credentialing Center (ANCC) 
Stanford Medicine designates this Enduring Material for a maximum of 1.0 ANCC contact hours.  

ASWB Approved Continuing Education Credit (ACE)
As a Jointly Accredited Organization, Stanford Medicine is approved to offer social work continuing education by the Association of Social Work Boards (ASWB) Approved Continuing Education (ACE) program. Organizations, not individual courses, are approved under this program. Regulatory boards are the final authority on courses accepted for continuing education credit. Social workers completing this activity receive 1.0 continuing education credits.

American Academy of Physician Assistants (AAPA) - Enduring Material
Stanford Medicine has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This Enduring Material is designated for 1.0 AAPA Category 1 CME credits. Approval is valid until July 6, 2026. PAs should only claim credit commensurate with the extent of their participation.  

American Psychological Association (APA) 
Continuing Education (CE) credits for psychologists are provided through the co-sponsorship of the American Psychological Association (APA) Office of Continuing Education in Psychology (CEP). The APA CEP Office maintains responsibly for the content of the programs.


Additional Information

Accessibility Statement
 Stanford University School of Medicine is committed to ensuring that its programs, services, goods and facilities are accessible to individuals with disabilities as specified under Section 504 of the Rehabilitation Act of 1973 and the Americans with Disabilities Amendments Act of 2008.  If you have needs that require accommodations, please contact the coordinator.

Cultural and Linguistic Competency
The planners and speakers of this CME activity have been encouraged to address cultural issues relevant to their topic area for the purpose of complying with California Assembly Bill 1195. Moreover, the Stanford University School of Medicine Multicultural Health Portal contains many useful cultural and linguistic competency tools including culture guides, language access information and pertinent state and federal laws.  You are encouraged to visit the Multicultural Health Portal: https://laneguides.stanford.edu/multicultural-health

References

Altier, N., & Stewart, J. (1998). Dopamine receptor antagonists in the nucleus accumbens attenuate analgesia induced by ventral tegmental area substance P or morphine and by nucleus accumbens amphetamine. The Journal of pharmacology and experimental therapeutics, 285(1), 208–215.

Amanzio, M., & Benedetti, F. (1999). Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems. The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(1), 484–494. https://doi.org/10.1523/JNEUROSCI.19-01-00484.1999

Baliki, M. N., Geha, P. Y., Fields, H. L., & Apkarian, A. V. (2010). Predicting value of pain and analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic pain. Neuron, 66(1), 149–160. https://doi.org/10.1016/j.neuron.2010.03.002

Bushnell, M. C., Duncan, G. H., Hofbauer, R. K., Ha, B., Chen, J. I., & Carrier, B. (1999). Pain perception: is there a role for primary somatosensory cortex?. Proceedings of the National Academy of Sciences of the United States of America, 96(14), 7705–7709. https://doi.org/10.1073/pnas.96.14.7705

Cormier, S., Lavigne, G. L., Choinière, M., & Rainville, P. (2016). Expectations predict chronic pain treatment outcomes. Pain, 157(2), 329–338. https://doi.org/10.1097/j.pain.0000000000000379

Dum, J., & Herz, A. (1984). Endorphinergic modulation of neural reward systems indicated by behavioral changes. Pharmacology, biochemistry, and behavior, 21(2), 259–266. https://doi.org/10.1016/0091-3057(84)90224-7

Eippert, F., Bingel, U., Schoell, E. D., Yacubian, J., Klinger, R., Lorenz, J., & Büchel, C. (2009). Activation of the opioidergic descending pain control system underlies placebo analgesia. Neuron, 63(4), 533–543. https://doi.org/10.1016/j.neuron.2009.07.014

Eippert, F., Finsterbusch, J., Bingel, U., & Büchel, C. (2009). Direct evidence for spinal cord involvement in placebo analgesia. Science (New York, N.Y.), 326(5951), 404. https://doi.org/10.1126/science.1180142

Fields H. (2004). State-dependent opioid control of pain. Nature reviews. Neuroscience, 5(7), 565–575. https://doi.org/10.1038/nrn1431

Franklin K. B. (1989). Analgesia and the neural substrate of reward. Neuroscience and biobehavioral reviews, 13(2-3), 149–154. https://doi.org/10.1016/s0149-7634(89)80024-7

Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A., & Morris, H. R. (1975). Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature, 258(5536), 577–580. https://doi.org/10.1038/258577a0

Jensen, J., McIntosh, A. R., Crawley, A. P., Mikulis, D. J., Remington, G., & Kapur, S. (2003). Direct activation of the ventral striatum in anticipation of aversive stimuli. Neuron, 40(6), 1251–1257. https://doi.org/10.1016/s0896-6273(03)00724-4

Keltner, J. R., Furst, A., Fan, C., Redfern, R., Inglis, B., & Fields, H. L. (2006). Isolating the modulatory effect of expectation on pain transmission: a functional magnetic resonance imaging study. The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(16), 4437–4443. https://doi.org/10.1523/JNEUROSCI.4463-05.2006

Kieffer B. L. (1999). Opioids: first lessons from knockout mice. Trends in pharmacological sciences, 20(1), 19–26. https://doi.org/10.1016/s0165-6147(98)01279-6

Manglik, A., Kruse, A. C., Kobilka, T. S., Thian, F. S., Mathiesen, J. M., Sunahara, R. K., Pardo, L., Weis, W. I., Kobilka, B. K., & Granier, S. (2012). Crystal structure of the µ-opioid receptor bound to a morphinan antagonist. Nature, 485(7398), 321–326. https://doi.org/10.1038/nature10954

Mitchell, J. M., O'Neil, J. P., Janabi, M., Marks, S. M., Jagust, W. J., & Fields, H. L. (2012). Alcohol consumption induces endogenous opioid release in the human orbitofrontal cortex and nucleus accumbens. Science translational medicine, 4(116), 116ra6. https://doi.org/10.1126/scitranslmed.3002902

Olds, J., & Milner, P. (1954). Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. Journal of comparative and physiological psychology, 47(6), 419–427. https://doi.org/10.1037/h0058775

Pavlov, I. P. (1927). Conditioned reflexes: an investigation of the physiological activity of the cerebral cortex. Oxford University Press.

Ren, W., Centeno, M. V., Berger, S., Wu, Y., Na, X., Liu, X., Kondapalli, J., Apkarian, A. V., Martina, M., & Surmeier, D. J. (2016). The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain. Nature neuroscience, 19(2), 220–222. https://doi.org/10.1038/nn.4199

Sato, D., Narita, M., Hamada, Y., Mori, T., Tanaka, K., Tamura, H., Yamanaka, A., Matsui, R., Watanabe, D., Suda, Y., Senba, E., Watanabe, M., Navratilova, E., Porreca, F., Kuzumaki, N., & Narita, M. (2022). Relief of neuropathic pain by cell-specific manipulation of nucleus accumbens dopamine D1- and D2-receptor-expressing neurons. Molecular brain, 15(1), 10. https://doi.org/10.1186/s13041-021-00896-2

Schmidt, B. L., Tambeli, C. H., Levine, J. D., & Gear, R. W. (2002). mu/delta Cooperativity and opposing kappa-opioid effects in nucleus accumbens-mediated antinociception in the rat. The European journal of neuroscience, 15(5), 861–868. https://doi.org/10.1046/j.1460-9568.2002.01915.x

Scott, D. J., Stohler, C. S., Egnatuk, C. M., Wang, H., Koeppe, R. A., & Zubieta, J. K. (2008). Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses. Archives of general psychiatry, 65(2), 220–231. https://doi.org/10.1001/archgenpsychiatry.2007.34

For activity related questions, please contact

     Name: Holly Meyer
     Title: CME Compliance Coordinator
     Email: [email protected]

For CME general questions, please contact 
 
   Email: [email protected]



Mitigation of Relevant Financial Relationships


Stanford Medicine adheres to the Standards for Integrity and Independence in Accredited Continuing Education.

There are no relevant financial relationships with ACCME-defined ineligible companies for anyone who was in control of the content of this activity, except those listed in the table below. All of the relevant financial relationships listed for these individuals have been mitigated.



Member Information
Role in activity
Nature of Relationship(s) / Name of Ineligible Company(s)
Beth D Darnall, PhD
Professor, Anesthesiology, Perioperative and Pain Medicine; Clinical Professor (By courtesy), Psychiatry and Behavioral Sciences
Stanford University
Course Director
Advisor-AppliedVR
Howard L Fields, MD, PhD
Professor of Neurology
Not affiliated with Stanford Medicine
Faculty
Nothing to disclose
Matthias Cheung, PhD
Adjunct Professor Pharmacy Practice
University of the Pacific
Planner
Nothing to disclose
Corinne Cooley, PhD
Physical Therapist
Stanford HealthCare
Planner
Nothing to disclose
Sara Davin, PsyD
Director
Cleveland Clinic
Planner
Nothing to disclose
Steve Denton, LCSW
Director of Consultation Liaison & Behavioral Health Integration
Lehigh Valley Health Network
Planner
Nothing to disclose
Ashley Gomez, BA
Stanford University
Planner
Nothing to disclose
Sean Charles Mackey, MD, PhD
Redlich Professor; Chief, Division of Stanford Pain Medicine
Stanford Health Care (SHC)
Planner
Nothing to disclose
Theresa Mallick-Searle, NP
Nurse Practitioner
Stanford Health Care
Planner
Speakers Bureau-Averitas|Speakers Bureau-Salix
Amanda Zimmerman, PA
Physician Assistant
West Forsyth Pain Management
Planner
Nothing to disclose

Stanford Pain Relief Innovations Lab Guest Speaker Series: Self-Fulfilling Prophecies: How Predictions and Expectations Modulate Pain (RECORDING) module
INSTRUCTIONS: Click Launch YouTube to watch the video on YouTube. Next, click the Attestation button. Attest to your participation, view results, and complete the evaluation. After successful completion, your credit transcript will be available to view and download immediately in MY CE portal. 

Can’t find the evaluation? Click the My CE button and select the Evaluation and Certificates tile. Select the Complete Evaluation button associated with the activity.
Launch YouTube Attestation

 

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