Pediatric Grand Rounds (RECORDING) Haploidentical Stem Cell Transplantation: You’ve Always Got a Donor, Why Not Always Use It?

Wednesday, December 15, 2021, 12:00 AM - Thursday, December 15, 2022, 12:00 AM PST

This presentation is a recording of a Stanford Pediatric Grand Rounds Session.  World-renowned experts will present the latest research, practice guidelines, and treatment protocols to advance best practices in the care of pediatric patients. These online recordings will provide pediatricians and family physicians with up-to-date clinical information on a wide range of clinical issues encountered in daily pediatric practice. 

Hematopoietic stem cell transplantation (HSCT) is the only curative treatment for many disorders, including malignant and non-malignant disorders. However, a fully matched related donor is available only for 25% of patients, and, despite over 31 million of volunteer donors, about 50% patients cannot find a suitable donor in a reasonable frame-time. Therefore, strategies to optimize the use of mismatched donors are urgently needed. The use of donors HLA-partially matched (haploidentical) is becoming widely used and in 2021 we can say that, thanks to new graft manipulation strategies we have a donor for everyone.

  Release Date: December 15, 2021
  Expiration Date: December 15, 2022
  Estimated Time to Complete: 1 hour 
  Registration Fee: FREE

*Originally recorded 9/24/2021.

AMA PRA Category 1 Credits™ (1.00 hours), Non-Physician Participation Credit (1.00 hours)

1. Evaluate emerging research, updated guidelines, and treatment protocols in order to develop strategies for best practice in the care of pediatric patients.
2. Describe how the use of abhaplo-HSCT enables functional immune tolerance towards solid organ transplantation
3. Implement strategies to optimize the use of mismatched donors

In support of improving patient care, Stanford Medicine is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. 

Credit Designation 
American Medical Association (AMA) 
Stanford Medicine designates this Enduring Material for a maximum of 1.00 AMA PRA Category 1 Credits^TM.  Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Accessibility Statement
 Stanford University School of Medicine is committed to ensuring that its programs, services, goods and facilities are accessible to individuals with disabilities as specified under Section 504 of the Rehabilitation Act of 1973 and the Americans with Disabilities Amendments Act of 2008.  If you have needs that require special accommodations, including dietary concerns, please contact the CME Conference Coordinator.

Cultural and Linguistic Competency
The planners and speakers of this CME activity have been encouraged to address cultural issues relevant to their topic area for the purpose of complying with California Assembly Bill 1195. Moreover, the Stanford University School of Medicine Multicultural Health Portal contains many useful cultural and linguistic competency tools including culture guides, language access information and pertinent state and federal laws.  You are encouraged to visit the Multicultural Health Portal: https://laneguides.stanford.edu/multicultural-health

References/Bibliography
Pulsipher M. Haplo is the new black. Blood. 124(5): 675–676, 2014.

Bertania A et al. Unrelated donor vs HLA-haploidentical alpha/beta T-cell and B-cell depleted HSCT in children with acute leukemia. Blood. 132 (24): 2594–2607. 2018.


For CME general questions, please contact 
     Email: [email protected]

Mitigation of Relevant Financial Relationships

Stanford Medicine adheres to the Standards for Integrity and Independence in Accredited Continuing Education. 

There are no relevant financial relationships with ACCME-defined ineligible companies for anyone who was in control of the content of this activity, except those listed in the table below. All of the relevant financial relationships listed for these individuals have been mitigated.